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segunda-feira, 31 de março de 2014

SKIN CANCER: NEITHER MY GREAT-PARENTS NOR MY PARENTS HAD...BUT I HAVE. WHAT DOES THIS MEAN?

This means, in my view, that since we had quite similar way of life in the tropics (Northeastern Brazil), I have been exposed since  my childhood and professional life as an ecologist, to much higher incidence of UV light than my ancestors had.


'Step forward' in skin cancer fight

Last updated 30/03/2014 14:01 BRT

By Helen Briggs

[Reproduced from BBC News, on line]


Scientists say they have taken a step forward in understanding why some people are at greater risk of skin cancer because of their family history.

A newly identified gene mutation causes some cases of melanoma, a type of skin cancer, says a UK team.

The discovery will pave the way for new screening methods, they report in Nature Genetics.

The risk of melanoma depends on several factors, including sun exposure, skin type and family history.

Every year in the UK, almost 12,000 people are diagnosed with melanoma.

About one in 20 people with melanoma have a well-established family history of the disease.

A team led by the Wellcome Trust Sanger Institute in Hinxton, UK, found that people with mutations in a certain gene were at extremely high risk of melanoma.

The mutations switch off a gene known as POT1, which protects against damage to packets of DNA, known as chromosomes.

Co-author Dr David Adams, from the Wellcome Trust Sanger Institute, said the discovery should lead to the ability to find out who in a family was at risk, and who should be screened for skin cancer.

He told the BBC: "The mutations in this gene result in damage to the end of the chromosomes and chromosomal damage in general is linked to cancer formation - that's the pathway for it."

Early detection

A number of gene mutations have been identified as increasing the risk of melanoma, but others remain unknown.

Prof Tim Bishop, Director of the Leeds Institute of Cancer and Pathology, said the finding increased understanding of why some families had a high incidence of melanoma.

"Since this gene has previously been identified as a target for the development of new drugs, in the future it may be possible that early detection will facilitate better management of this disease," he said.

The team found cancers such as leukaemia were common in these families, suggesting the gene may underlie other cancers and not just melanoma.

Dr Safia Danovi of Cancer Research UK said: "This is a step forward for people with a strong family history of melanoma, the most dangerous form of skin cancer.

"But it's important to remember that, for most of us, avoiding sunburn and sunbeds is the best way to reduce the risk of this disease."

BBC © 2014

quinta-feira, 27 de março de 2014

WEST NILE VIRUS MAY HAVE MET ITS MATCH: TOBACCO

[Reproduced from THE VERGE; published in PLOS ONE:
DOI: 10.371/journal.pone.0093541] 

Some people think of tobacco as a drug, whereas others think of it as a therapy — or both. But for the most part, it's hard to find people who think of the tobacco plant in terms of its medical applications. Qiang Chen, an infectious disease researcher at Arizona State University, is one such person. His team of scientists conducted an experiment, published today in PLOS ONE, that demonstrates how a drug produced in tobacco plants can be used to prevent death in mice infected with a lethal dose of West Nile virus. The study represents an important first step in the development of a treatment for the mosquito-borne disease that has killed 400 people in the US within the last two years.

Some people think of tobacco as a drug, whereas others think of it as a therapy — or both. But for the most part, it's hard to find people who think of the tobacco plant in terms of its medical applications. Qiang Chen, an infectious disease researcher at Arizona State University, is one such person. His team of scientists conducted an experiment, published today in PLOS ONE, that demonstrates how a drug produced in tobacco plants can be used to prevent death in mice infected with a lethal dose of West Nile virus. The study represents an important first step in the development of a treatment for the mosquito-borne disease that has killed 400 people in the US within the last two years.


The mice evaded death

In the study, scientists introduced a gene that produces monoclonal antibodies (MAbs) — proteins derived from cloned immune cells that fight off disease — into a "deconstructed" plant virus vector. Then, they introduced the vector into the tobacco plants. "The vector is in the plant transiently for about 10 days," Chen said in an email to The Verge. During this period, the virus vector produces a large amount of MAbs that the researchers can then extract, after harvesting the plants.

Once extracted, the scientists injected the MAbs into mice that had already been infected with West Nile virus. The results of the study show that in 90 percent of cases, the mice evaded death — and eventually made a full recovery.

Preventing the virus from entering brain cells

The reason MAbs can neutralize the virus is because they are able to target and bind to proteins located on its surface. This binding action is what prevents the virus from entering the mouse's brain cells and causing lethal neurological damage. And because West Nile virus can take a few days to settle into its host's cells, the treatment was effective even four days after the viral injection.

This isn't the first MAb-based treatment that scientists have been able to use against West Nile virus. But previous attempts to produce MAbs involved making them in animal cells. That approach is not only expensive, but is also carries a risk for the transmission of human or animal pathogens, the researchers wrote in the study. Here, the scientists used tobacco plants because they are capable of producing a large amount of proteins and seeds — properties that make them ideal candidates for scaling-up production, Chen explained. So, thanks to these plants, the researchers were able to develop a therapeutic candidate that is "more efficacious and cheaper to make" than previous attempts, Chen said — an advancement that could make a big difference for healthcare providers and patients in developing countries.

These tobacco-derived MAbs have not been tested on humans, however, so the results of this study are a far cry from a cure for West Nile virus. "The next step will be to enhance the ability of MAbs to penetrate into the brain, where the virus does most of the damage," Chen said. Yet, should the drug prove effective in future trials, the tobacco plant might one day be associated with more than smoke-related cancer, as it could also help prevent thousands of people from suffering serious neurological complications, and even death.

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terça-feira, 25 de março de 2014

CRISIS OF WATER IN BRAZIL!? OR CRISIS OF INTELLIGENCE FOR ACTIONS IN SUSTAINABLE DEVELOPMENT???

Coming in an election year, every opposition party takes advantage of the failures of the ruler to structure its campaign platform. Not many opposition parties however, initiate open dialogue and draw up feasible and comprehensive plans which can be implemented to solve problems, mainly in environmental issues.
In the case of water (the greatest of Nature resources), one of the first actions politicians talk about is the transposition of rivers which has started by the rio São Francisco river (St. Francis River) intended to save the suffering Northeast region of Brazil; and now discussions are being carried out on capturing water from Paraíba do Sul River, of Rio de Janeiro state, (believe) to save the huge city of São Paulo that is suffering a long period of dryness.
The real solution is not a priority in political discussions: the revitalization  of water sources. The problem of water scarcity over here, is frequently attributed to divine responsibility. They often ask: what can we do if  it doesn't rain!?
In the case of the São Francisco River there is a good project about its revitalization. The people should have sufficient awareness and training, to require its complete execution. It seems that such execution may not have been fully performed. Recent press release, here in Joao Pessoa, accounted for populations to be benefited with such transposition (when and if it occurs) will be receiving polluted water; the sanitation in cities along the river is of crucial importance, but it does not have been fully performed!!!
Do readers remember  the lobbyists succeeded in making rural profitability with the Brazilian forest code modifications? handicapping the riverbanks and hillsides of hills???
In the case of São Paulo capital, it is important that actions of "environmental services" such as the one  carried out in the municipality of Extrema (MG) (an initiative with the TNC-The Nature Conservancy) are disseminated for providing more water to São Paulo. 
The  initiative  of Extreme municipality was recognized in international awards, in Dubai, Arab Emirates, and widely disseminated by Rede Globo TV. Access the video (in Portuguese):

sábado, 22 de março de 2014

THE DAY HUMANS WILL KILL EACH OTHER FOR WATER...

Water  in Palestine - a crime against humanity?

Ayman Rabi

[Reproduced from  (where the complete article can be read): http://www.theecologist.org/News/news_analysis/2329259/water_apartheid_in_palestine_a_crime_against_humanity.html   22nd March 2014]


Farmer Fadel Jaber is arrested for 'stealing water' in the Palestinian village of Sussia, on South Mt. Hebron. Israel has constructed water pipes in the area, but they only serve the army and the settlers. The Palestinians are forced to drive to the closest town, and buy their water in tanks over there. Photo: noam / www.promisedlandblog.com


Systematic, acute, malicious discrimination in access to water in the West Bank and Gaza, 

combined with massive resource theft, is operated by the occupation authorities and the private water company Mekorot, writes Ayman Rabi on UN World Water Day.

Settlements benefit from Penough water to run farms and orchards, and for swimming pools and spas, while Palestinians often struggle to access the minimum water requirements.

Today is UN World Water Day - a day to remember the billion people who are unable to meet their needs for safe, clean water due to drought, poverty and official neglect.

But it's also a day to remember, and fight for, 2.1 million Palestinians who suffer something different - an artificial water scarcity deliberately created and sustained by Israel's military occupation, and the private Israeli water company Mekorot.

Increased international pressure brings hope that the tide may be finally turning for Palestinians striving for water justice in the West Bank and Gaza - in particular, recent investment and partnership decisons against Mekarot, which runs Israel's discriminatory water policy in the West Bank.

Waterless in Gaza and East Jerusalem

The situation in Gaza is especially dire. The tiny, densely populated territory relies entirely on its depleted, saltwater-contaminated and sewage-polluted aquifer, and the water it produces is unfit for consumption. Water has to be bought, expensively, in bottles or from mobile tanks.

Moreover restrictions on fuel imports mean that Gaza's single power station spends most of its time idle - and so long as it's not running water and sewage cannot be pumped. So the taps are dry, toilets are blocked, and sewage pollution gets worse.

Not that Palestinian residents of East Jerusalem have it a lot better. As reported on 17th March, the city suffered a long water cut beginning on 4th March leaving Ras Shehada, Ras Khamis, Dahyat A'salam and the Shuafat refugee camp - cut off from the rest of the city by the separation wall - with no running water.

The reason is simple - old and inadequate water infrastructure, which there are no plans to improve or renew.


quarta-feira, 19 de março de 2014

TREE PLANTATION IN BEIJING WILL SOLVE AIR POLLUTION CHALLENGE???


TREE PLANTATION IN BEIJING WILL SOLVE AIR POLLUTION CHALLENGE???

Planting forests across Beijing could help combat pollution

Forbidden forest to replace the Forbidden City? myheimuCC BY-NC

Smog has become an unfortunate feature of Chinese city skylines. Air pollution has gotten so bad in recent years thatcitizens have rallied and the government has declared a war upon it. One weapon in their arsenal is to plant an army of trees that will help neutralise pollution particles in the air.

Beijing, the seat of the government, is on China’s industrial east coast and has been affected as much as the next city by polluted air. Faced with the challenge, the local Beijing government initiated a program in 2012 that will invest a total of 30 billion RMB (US$4.7 billion) to construct 67,000 hectares of trees around Beijing in the next few years. That’s the equivalent of two hundred Central Parks, spread across the city.

Pollution reducers

Adopting this unconventional control measure on such a large scale is a bold move for the local government in Beijing. But, studies have shown that trees can reduce smog particles in the air both directly and indirectly. To directly reduce them, tree canopies can intercept particles already existing in the air. Indirectly, trees can lower air temperatures through providing shade and evapotranspiration (when water is taken up into the atmosphere off and through vegetation).

The cooling effect this has reduces the need for energy-using fans and air conditioners, which further lowers emissions. Also, the rates of photochemical reactions in the urban atmosphere are slowed down by the lowered air temperature and less secondary air pollutants are produced.

The species of trees to use and where to plant more than 100 million of them can have a significant impact on the effectiveness of this control measure in Beijing. Trees can actually become a source of air pollution too. Some tree species are high emitters of biogenic volatile organic compounds. These react with nitrous oxides and other chemicals in the air to form ozone and secondary organic aerosols, which are tiny “tar balls” found to have bad health effects. Ozone is the main component of urban smog and secondary organic aerosols are also a source.

It has even been suggested that more vegetation in urban environments could reduce the dispersion of smog particles from urban areas. Urban forests can potentially decrease the strength of convective mixing – where air pollutants are lofted up and away from the surface, taking them out of contact with people. The “urban boundary layer” of the urban atmosphere is also lowered, trapping heat and pollutants closer to the the earth’s surface. So it’s important that the right trees are planted.

Mixed results

Supported by the National Geographic Air and Water Conservation Fund, my group is currently studying just how effective urban forests could be in Beijing. The initial results from our study are mixed. Trees planted in the last two years can reduce pollution particles from Beijing’s air, but the magnitude of removal is far lower than the government would hope.

Six tree species that have been used extensively in planting across the city are high emitters of the potentially problematic biogenic volatile organic compounds, which could add to problems down the line. Currently we are still in the process of modelling what the long-term effects will be once all the trees have been planted and matured. This means it’s too early to say what the final impacts of trees are on smog particles in Beijing.

But, based on a study of ten US cities, urban trees did remove smog particles and improve the air quality of those cities by 0.05%-0.24%. Based on this, the improvement would be higher in Beijing due to the higher concentration of smog particles, though the reduction is unlikely to be as significant as hoped for by the government.

So, what is the message for other cities? Making cities greener by planting urban forests should not be treated as a stand-alone air pollution control measure. In fact, measures that are more effective but also more painful to implement should be giving the priority, such as reducing the use of cars.

Urban forests can play an important role in making cities nicer places to live and they do have cooling, pollution-reducing effects. But, it’s important to remember that it is our growing use of cars and industrial emissions that are the source of the smog; sadly no amount of trees can counteract this.

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sábado, 15 de março de 2014

CURITIBA: OUR BRAZILIAN ECOCITY

Curitiba: the Greenest city on Earth

[Reproduced from THE ECOLOGIST, by Brian Barth]

15th March 2014

Football fans around the globe have their eyes set on Curitiba, Brasil this year, the site of the 2014 World Cup. But as Brian Barth reports, eco-savvy urban planners have been studying Brasil's seventh largest city for decades ...

This city is not for cars - Jaime Lerner, three-time Mayor of Curitiba

The story of Curitiba (the ti is pronounced like the chee in cheese) is one of the holy scriptures ofsustainable urban development, now replicated by many other ailing metropolises around the globe.

Curitiba's eco-city initiatives began long before the current mandate to clean up cities was born, their phenomenal success a product of a political climate with a humble problem-solving approach, rather than the usual grand-standing.

A pastoral city

With 52 square meters of green space per capita, Curitiba is truly the 'greenest' city in the world. Many of the smaller parks are dedicated to one of the ethnic groups that have settled in the city. Filled with shrines to the cultures of the world, they are enchanting oases of shade and quiet in the urban environs.

Within the larger tracts of green space, there is a world-class botanical garden and an opera house built in the dramatic setting of an abandoned quarry, its glass walls shimmering with magic in the water's reflection.

Curitiba's parks serve an ecological function, as well. Much of the 400 square kilometres of parkland doubles as a naturalized, decentralized stormwater management facility.

In most cities, a massive river like the Iguacu would be channelized between concrete walls in an attempt to control flooding and maximize developable land along the riparian corridor.

In contrast, Curitiba's park system was designed to preserve the river's meandering course. During heavy rains the river backs up and spreads out into the low-lying area of the parks, forming temporary lakes and mimicking a natural floodplain.

Ultra-efficient transit

Curitiba's bus rapid transit system (BRT) satisfies 70 to 80 percent of the daily trips made by Curitibanos, resulting in 25% lower carbon emissions per capita than the average for Brasilian cities.

The beauty of BRT is its efficiency: its ability to move people around the city quickly (thus reducing dependency on automobile use) compares favorably to underground or elevated rail systems, but the infrastructure can be built for a fraction of the cost.

In a typical public bus system, buses are subject to the same traffic congestion as private vehicles, a limitation circumvented by dedicated rail lines.

In a BRT system, buses have exclusive access to a central right-of-way where they move unimpeded by other vehicular traffic; this is flanked on either side by one way streets for the circulation of private vehicles.

By combining the advantages of light rail with the affordability of bus transit, precious municipal funds can be redirected to other important programs-a concept pioneered in Curitiba and now used in many other cities.

Empowering the populace to keep Curitiba clean

Brasil is infamous for its favelas - unplanned slums inhabited by disenfranchised members of society, usually groups that have migrated to the city from rural areas in search of work.

Curitiba has never been immune to the phenomenon but has dealt with the issue with greater success than many of its counterparts in the developing world.

One of the more heart-warming examples is a program that exchanges trash and recyclables for bus tokens, food and cash. Participants are known as carinheiros, which is best translated as 'those that give tender loving care'.

Because of the carinheiros' TLC, Curitiba is astonishingly clean and the affectionate name they've been endowed with shows how much their work is appreciated and celebrated by the general populace.

By empowering people with access to transportation and meaningful work, Curitiba has created dynamism at its lowest socio-economic rungs, propelling upward mobility and decreasing dependence on government support.

Today, Curitiba is one of the most prosperous cities in Latin America; per capita income is 66% higher than the Brasilian average.

Planning instead of politics

Southern Brasil is not where you would expect to find the city that chartered the course towards urban sustainability for the rest of the world. The unique culture of enlightened urban policy and citizen engagement first emerged in Curitiba in the 1960s in a strangely ironic brew of circumstances.

The events that set the stage for Curitiba's success are less than admirable: the military dictatorship that ruled Brasil between 1964 and 1985 meant that government officials were appointed, not elected, and could impose whatever they wished within their jurisdiction.

Curitiba is a rare example of this power being used with noble intentions, a fact that has everything to do with its three-time mayor, Jaime Lerner.

Lerner could be seen as a benevolent dictator, but he was an architect and urban planner by trade - not a politician - and his vision of what a city could be was backed with a profound understanding of how to make it happen.

Though Lerner's 'sustainability regime' was force-fed to the city in the beginning, the results were so positive he was elected by an overwhelming majority after democracy was restored in Brasil in the 1980's.

Thanks to Lerner and his cohorts, Curitiba is a rare city where the language of urban planning is part of the common parlance. In this unassuming eco-city, pragmatism regularly wins out over politics and environmental ethics have squarely supplanted the conventional tactics of economic development.

After visiting Curitiba, Bill McKibben, founder the 350.org movement, lavished his praise on the place: "I met very few cynics. The resigned weariness of westerners about government, which leaves only fanatics and hustlers running for office, had lifted from this place."

 


 

Brian Barth is a freelance writer and landscape architect. Particular interests include the interdependence of people, plants, and the Earth; communicating the complex systems of design, urban ecology, and urban planning to a general audience; the dynamics of development patterns and ecosystem integrity in urban areas; and engaging public awareness in the ecological processes of a given site.

domingo, 9 de março de 2014

EPIGENETICS: PROVOCATIVE DISCUSSION ON 'ENVIRONMENT AFFECTING INHERITANCE"

Epigenetics, may confirm: "T.H. Dobzhansky: Nothing in biology makes sense, except in the light of evolution" and, as said M. Begon, "Nothing in evolution and biology itself makes sense, except in the light of ecology". Watch the video from BBC Documentary: http://youtu.be/urQxDu7r_2M

OZONE DEPLETION: A DIFFICULT PROBLEM TO BE SOLVED






[Reproduced from BBC NEWS - Online]
The evidence quickly pointed to CFC gases, which were invented in the 1920s, and were widely used in refrigeration and as aerosol propellants in products like hairsprays and deodorants.

Now, researchers from the University of East Anglia have discovered evidence of four new gases that can destroy ozone and are getting into the atmosphere from as yet unidentified sources.

Three of the gases are CFCs and one is a hydrochlorofluorocarbon (HCFC), which can also damage ozone. "Our research has shown four gases that were not around in the atmosphere at all until the 1960s which suggests they are man-made," said lead researcher Dr Johannes Laube.
The researchers also looked at modern air samples, collected at remote Cape Grim in Tasmania.
They estimate that about 74,000 tonnes of these gases have been released into the atmosphere. Two of the gases are accumulating at significant rates.
"The identification of these four new gases is very worrying as they will contribute to the destruction of the ozone layer," said Dr Laube.
"Of the four species identified, CFC-113a seems the most worrying as there is a very small but growing emission source somewhere, maybe from agricultural insecticides. We should find it and take it out of production."







sexta-feira, 7 de março de 2014

FANATICS FOR BARBECUE!? GET READY FOR DEMENTIA!!!


Eating barbecued and fried food could increase risk of dementia, say scientists

Protein-rich foods cooked at very high temperatures raise the level of harmful Ages - compounds called advanced glycation end products - in blood
Getty
Risk: Family cooking barbecue in garden
Eating barbecued, grilled or fried meat could increase the risk of being struck down by dementia, scientists have discovered.
Research by US experts suggests that compounds called advanced glycation end products, or Ages, suppress an anti-ageing enzyme known as Sirt1.
Protein-rich foods that are cooked at very high temperatures raise the level of these harmful Ages in blood.
The scientists found mice that were fed Ages accumulated a brain protein which is a key indicator of dementia in humans.
Researchers said their follow-up study of 93 people aged over 60 showed that those with high amounts of Ages in their blood suffered progressive mental decline.
Professor Helen Vlassara, who led the probe, said: “Because Ages can be modified in humans, recognition that this under-appreciated risk factor plays a role in AD [age-related dementia] may open unique therapeutic avenues.”
The scientist, of Icahn School of Medicine at Mount Sinai in New York, added “larger clinical trials are warranted”.
British experts said the findings were interesting but should be treated with caution.
Prof Derek Hill, of University College London, said: “There is a great deal of public interest in the way that diet can cause, or prevent, serious diseases in older life.
"Some of the proposed ‘bad guys’ in the diet are Ages, which are present in especially high quantities in meat that is cooked by frying or grilling.
“The results are compelling. But this study should be seen as encouraging further work, rather than as providing definitive answers.”
Scientists began linking Ages to Alzheimer’s disease in the 1990s but this research, published in the Proceedings of the National Academy of Sciences journal, is the most comprehensive study of the compounds.
Dr Simon Ridley, of Alzheimer’s Research UK, said it was “important to note that the people in this study did not have dementia”.
He added: “This subject has not yet been well studied in people, and we don’t yet know whether the amount of Ages in our diet might affect our risk of dementia.”


http://www.mirror.co.uk/lifestyle/health/dementia-research-eating-barbecued-fried-3180552#ixzz2vHDRmxug
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