Eating barbecued and fried food could increase risk of dementia, say scientists
http://www.mirror.co.uk/lifestyle/health/dementia-research-eating-barbecued-fried-3180552#ixzz2vHDlZrnn
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Protein-rich foods cooked at very high temperatures raise the level of harmful Ages - compounds called advanced glycation end products - in blood
Eating barbecued, grilled or fried meat could increase the risk of being struck down by dementia, scientists have discovered.
Research by US experts suggests that compounds called advanced glycation end products, or Ages, suppress an anti-ageing enzyme known as Sirt1.
Protein-rich foods that are cooked at very high temperatures raise the level of these harmful Ages in blood.
The scientists found mice that were fed Ages accumulated a brain protein which is a key indicator of dementia in humans.
Researchers said their follow-up study of 93 people aged over 60 showed that those with high amounts of Ages in their blood suffered progressive mental decline.
Professor Helen Vlassara, who led the probe, said: “Because Ages can be modified in humans, recognition that this under-appreciated risk factor plays a role in AD [age-related dementia] may open unique therapeutic avenues.”
The scientist, of Icahn School of Medicine at Mount Sinai in New York, added “larger clinical trials are warranted”.
British experts said the findings were interesting but should be treated with caution.
Prof Derek Hill, of University College London, said: “There is a great deal of public interest in the way that diet can cause, or prevent, serious diseases in older life.
"Some of the proposed ‘bad guys’ in the diet are Ages, which are present in especially high quantities in meat that is cooked by frying or grilling.
“The results are compelling. But this study should be seen as encouraging further work, rather than as providing definitive answers.”
Scientists began linking Ages to Alzheimer’s disease in the 1990s but this research, published in the Proceedings of the National Academy of Sciences journal, is the most comprehensive study of the compounds.
Dr Simon Ridley, of Alzheimer’s Research UK, said it was “important to note that the people in this study did not have dementia”.
He added: “This subject has not yet been well studied in people, and we don’t yet know whether the amount of Ages in our diet might affect our risk of dementia.”
http://www.mirror.co.uk/lifestyle/health/dementia-research-eating-barbecued-fried-3180552#ixzz2vHDRmxug
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